Delfi Diagnostics Selected as the Liquid Biopsy Partner for 4-IN-THE-LUNG-RUN: A Large-Scale European Lung Cancer Screening Study


The European Union is anticipated to launch a European lung cancer screening programme for people at risk due to their smoking and age based on the findings of the NELSON experiment.

Delfi Diagnostics has been chosen as the liquid lung cancer biopsy partner in Europe’s multi-national, randomised, prospective lung cancer screening trial known as 4-IN-THE-LUNG-RUN, or 4ITLR. Delfi Diagnostics is a pioneer in the development of a new class of high-performance, affordable liquid biopsy tests for early cancer detection and monitoring.

Through 4ITLR, European researchers are researching how frequently — annually or every other year — people should be examined after a negative initial CT scan. By testing whether Delfi can identify people in Europe’s screen-eligible population who are most likely to benefit from a CT scan, the technology is matched to the study objectives. Delfi will analyse the first 9,000 subjects enrolled through the trial in the Netherlands and France (Gustave Roussy) as part of the collaboration, which was started and made possible through a partnership between the Netherlands Cancer Institute ((NKI), with Dr. D. van den Broek as PI) and the institute for DiagNostic Accuracy (iDNA). This analysis will produce data that can support Delfi’s research and subsequent implementation within the European Union.

“One of the goals of our study is to examine how a liquid biopsy test might improve screening in a manner that is cost-effective”, “We are eager to explore how a low-cost liquid biopsy platform could help us screen more high-risk Europeans.”

prof. Matthijs Oudkerk, MD, PhD, Chief Scientific Officer at iDNA and leading the Radiology and AI readings of 4ITLR


“We know that LDCT screening is effective in reducing lung cancer mortality”, “This study should lay the groundwork for widespread, cost efficient screening of those at risk in Europe. Delfi is honored to be part of it.”

Peter B. Bach, Delfi Diagnostics Chief Medical Officer

Lung cancer kills more than 380,000 Europeans each year, and more than half of all new lung cancer diagnoses in Europe occur at stage IV, when 5-year survival rates can be as low as 2 percent. But screening older heavy smokers with low-dose CT could save up to 80,000 lives in Europe per year.

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